A high estrogenic environment
in utero may increase subsequent breast cancer risk. It was
therefore determined whether a maternal exposure during pregnancy
to the phytoestrogen genistein, which exhibit estrogenic activities
in vitro and in vivo, alters breast cancer risk among female
offspring. The results indicate that in utero exposure to genistein,
dose-dependently increased the incidence of breast tumors, when
compared with the controls. The number of estrogen receptor
binding sites was significantly elevated in the mammary glands
of genistein offspring.